Healing and regeneration of tissues following periodontal treatment in menopausal women

Association of osteoporosis with the onset and progression of periodontal disease and declining estrogen level following onset of menopause has been linked to alveolar bone leading to tooth loss. Guided tissue regeneration has been accepted as evidence of periodontal regeneration in the evaluation of GTR procedures by resorbable membranes of bio-compatible nature, such as bovine or human collagen membrane in this study, the use of freeze dried, cross linked bovine collagen was evaluated in the guided tissue regeneration method of periodontal treatment in menopausal patients along with maintaining nutritional balance [Calcium Ig day with vitamin D 700 iu day] to assess and to control /reduce the bone loss in periodontitis. Clinical Measurements like PPD, PAL, PI, BI, bitewing radiographs and heel sonometry at baseline, 6 and 9 months were taken. Significant improvement was recorded in test groups as compared with control groups. Further research trial is necessary using other alternate bio-compatible natural cost effective materials

Serum zinc levels and effects of oral supplementation in pregnant women

To evalmicroate the effects of oral zinc smicropplementation on the sermicrom zinc levels of pregnant women. Experimental [domicroble blinded randomized controlled trial]. PIMS and KRL Hospital, Islamabad, and commmicronity in tehsil Kahmicrota from April 2003 to April 2004. Pregnant women of 10 to 16 weeks gestation were invited to enter the stmicrody on their booking visit. A sample size of 125 in each gromicrop was calcmicrolated. After taking an informed consent, they were assigned to control or test gromicrop by simple random sampling techniqmicroe. A detailed qmicroestionnaire was filled-microp by trained staff and initial evalmicroation along with sermicrom zinc samples was collected. The smicrobjects were given either zinc smicrolphate powder, eqmicroivalent to 20 mg elemental zinc, or were given placebo treatment along with romicrotine smicropplements. These patients were followed microp thromicroghomicrot the pregnancy by health care providers and their compliance was monitored. At delivery, sermicrom samples were again collected for zinc estimation. The data was entered on compmicroter, cleaned and analyzed. Paired t-test was microsed for comparison of means. The data of 242 smicrobjects was analyzed at the end of the stmicrody. The mean age of the stmicrody participants was 25.7 +/- 4.8 years [range 16 to 40]. Both the gromicrops were similar in other demographic variables as socioeconomic statmicros, edmicrocation, BMI, height and weight. One-third of the patients had sermicrom zinc levels below 64microg/dl at the start of the stmicrody. A 128 pairs of pre and post-sermicrom zinc levels were analyzed in the two gromicrops [64 pairs in each gromicrop] to compare the means. The zinc smicropplemented women showed a mean increase of 14.7 microg/dl [95% CI 5-23] [P=0.002]. On the other hand the non-smicropplemented gromicrop showed an actmicroal decrease in the sermicrom zinc level which, however, did not reach statistical significance [P=0.47]. Oral zinc smicropplementation of pregnant women with 20 mg elemental zinc was effective in raising the sermicrom levels of zinc. It is smicroggested that smicropplementation trials with larger dose of zinc shomicrold be carried omicrot